Abstract

OBJECTIVE: This study aimed to compare the levels of systemic inflammation response index (SIRI) and panimmune inflammation value (PIV) in patients with benign, premalignant, and malignant laryngeal lesions and to determine the potential role of these indices in the differential diagnosis of laryngeal pathologies.

METHODS: This retrospective study was conducted with patients who underwent laryngeal biopsy between January 1, 2018, and June 1, 2023. Patients were categorized into three groups according to histopathological evaluation of the laryngeal lesion: benign, premalignant, and malignant. The SIRI and PIV were calculated for each patient. The groups were statistically compared in terms of age, complete blood count parameters, SIRI, and PIV.

RESULTS: Data from a total of 206 male patients (mean age: 58.8±12.9 years; range, 22 to 95 years) were analyzed. Of these 206 patients, 85 (41.3%) had malignant laryngeal lesions, 55 (26.7%) had premalignant laryngeal lesions, and 66 (32%) had benign laryngeal lesions. Despite the lack of statistical significance, the highest values for both indices were observed in the malignant group, while the lowest values were found in the benign group.

CONCLUSION: Although the SIRI and PIV tended to be higher in cases with malignant laryngeal lesions, this difference was not statistically significant. We propose that systemic inflammation indices should not be used as standalone diagnostic tools, but rather should be evaluated in conjunction with clinical, histopathological, and radiological findings.