Evaluation of total oxidant status, total antioxidant status, and oxidative stress index in patients with serous otitis media
Abdullah Özdem1, Fadlullah Aksoy2, Remzi Doğan2, Orhan Özturan2, Suat Turgut1
1Şişli Etfal Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği, İstanbul, Türkiye
2Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, İstanbul, Türkiye
Keywords: Antioxidative capacity, effusion, oxidative capacity, serous otitis.
Abstract
OBJECTIVE: This study aims to investigate the levels of total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in the serum of patients with serous otitis media (SOM) to clarify the etiopathogenesis and contribute to potential therapeutic and preventive strategies.
METHODS: This controlled, cross-sectional study included 30 patients (SOM group; 16 males, 14 females; mean age: 46.3±8.2 years; range, 20 to 80 years) and 30 healthy volunteers (control group; 18 males, 12 females; mean age: 47.8±9.5 years; range, 20 to 80 years) who presented to the otolaryngology clinic between January 2022 and December 2024. Peripheral venous blood samples were obtained from all participants before any treatment. Serum TAS, TOS, and OSI values were measured and compared between the groups.
RESULTS: There was no statistically significant difference between groups regarding age and sex distribution. SOM group had significantly higher TOS (13.8±7.5 vs. 3.4±0.6 µmol hydrogen peroxide equivalent/L) and OSI values (0.113±0.04 vs. 0.018±0.01) compared to control group (p=0.001). TAS values were significantly lower in the SOM group than control group (1.21±0.34 vs. 1.84±0.50 mmol Trolox equivalent/L; p=0.001).
CONCLUSION: Our findings indicate elevated oxidative stress and reduced antioxidant capacity in SOM patients. These results highlight the potential role of oxidative imbalance in SOM pathogenesis and suggest the need for further studies on antioxidant-based therapies.