How does allergen-specific immunotherapy affect mean platelet volume and complete blood inflammation markers?
Zehra Çınar1, Özgür Yiğit1, Ela Araz Server1, Füsun Erdenen2
1Sağlık Bilimleri Üniversitesi, İstanbul Eğitim Ve Araştırma Hastanesi, Kulak Burun Boğaz Ve Baş Boyun Cerrahisi Kliniği, İstanbul, Türkiye
2Sağlık Bilimleri Üniversitesi, İstanbul Eğitim Ve Araştırma Hastanesi, İç Hastalıkları Alerji Ve İmmunoloji Kliniği, İstanbul
Keywords: Allergen specific immunotherapy, allergic rhinitis, basophil, basophil-to-lymphocyte ratio, complete blood inflammation markers, mean platelet volume.
Abstract
OBJECTIVE: This study aims to investigate how allergen-specific immunotherapy (ASI) affected mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-lymphocyte ratio (ELR), basophil-to-lymphocyte ratio (BLR), and lymphocyte-to-monocyte ratio (LMR), which are essential indicators of systemic inflammation.
METHODS: Medical records of a total of 19 patients (7 males, 12 females; mean age: 33 years; range, 18 to 45 years) who received ASI for medical treatment-resistant seasonal or perennial allergic rhinitis (AR) and 24 healthy individuals (12 males, 12 females; mean age: 34 years; range, 18 to 45 years) were retrospectively analyzed between January 2015 and January 2020. The patients were divided into three groups as follows: control group including healthy individuals (Group 1, n=24); pre-immunotherapy (PreIT) treatment (Group 2, n=19); and post-immunotherapy (PostIT) treatment group (Group 3, n=19). The prespecified markers were calculated from the routine complete blood count analyses and the results were compared among the PreIT, PostIT, and control groups.
RESULTS: The MPV after ASI significantly increased in the PostIT group, compared to the PreIT group (p<0.05). The platelet, neutrophil, eosinophil, lymphocyte, and monocyte counts and PLR, NLR, ELR, and LMR values of the PostIT group did not significantly differ, compared to the PreIT group (p>0.05). Basophil and BLR values of the PostIT group significantly decreased, compared to the PreIT group (p<0.05).
CONCLUSION: Based on these results, it can be concluded that not only local inflammation, but also systemic inflammation contribute to the pathogenesis of AR, and not only local inflammation, but also systemic inflammation can be suppressed with ASI.