Association between extensive tympanosclerosis and serum calcium, phosphorus, vitamin D, and parathyroid hormone levels
Murat Doğan1, Ali Bayram1, İbrahim Hira1, Işıl Çakır2, İbrahim Özcan1
1Kayseri Eğitim ve Araştırma Hastanesi Kulak Burun Boğaz Hastalıkları Kliniği, Kayseri, Türkiye
2Kayseri Eğitim ve Araştırma Hastanesi Biokimya Kliniği, Kayseri, Türkiye
Keywords: Calcium, parathyroid hormone, phosphorus, tympanosclerosis, vitamin D.
Abstract
OBJECTIVE: This study aims to investigate the association between extensive tympanosclerosis and serum levels of calcium, phosphorus, vitamin D, and parathyroid hormone.
METHODS: This study was conducted in the Department of Otorhinolaryngology Head and Neck Surgery of the Kayseri Training and Research Hospital between October 2014 and May 2015. Thirty-seven patients who were diagnosed with extensive tympanosclerosis were assigned as a study group (18 males, 19 females; mean age 35.4 years; range 18 to 77 years). Thirty-two healthy subjects (15 males, 17 females; mean age 32.2 years; range 18 to 67 years) were recruited as a control group. Serum total calcium, phosphorus, vitamin D, parathyroid hormone and albumin levels were analyzed for each subject in the study. Total calcium levels were corrected based on the serum albumin levels to obtain albumin corrected calcium.
RESULTS: While the mean values of serum phosphorus, vitamin D and parathyroid hormone were significantly higher in the study group, the difference was not significant for serum levels of total calcium and albumin corrected calcium between the two groups.
CONCLUSION: Although serum phosphorus, vitamin D and parathyroid hormone levels were found to be relevant for extensive tympanosclerosis in this study group, further studies are required to investigate the potential role of these serum parameters in cellular mechanisms of tympanosclerosis development.