Relationship between vitamin D levels and inflammation in patients with recurrent tonsillitis and hypertrophic tonsil
İhsan Delioğlu1, Emrah Sapmaz2, Zeliha Cansel Özmen3
1Elbistan Devlet Hastanesi Kulak Burun Boğaz Kliniği, Kahramanmaraş, Türkiye
2Tokat Gaziosmanpaşa Üniversitesi Tıp Fakültesi Kulak Burun Boğaz Anabilim Dalı, Tokat, Türkiye
3Tokat Gaziosmanpaşa Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Tokat, Türkiye
Keywords: Recurrent tonsillitis, tonsil hypertrophy, vitamin D.
Abstract
OBJECTIVE: This study aimed to study the relationship between vitamin D levels and inflammation in patients with recurrent tonsillitis and hypertrophic tonsils.
METHODS: Sixty patients who were admitted between October 2016 and February 2018 and who either had indications for operation due to recurrent tonsillitis (n=30) or tonsillar hypertrophy (n=30) were included in the prospective study. Thirty healthy volunteers who applied to our clinic were included in the study as the control group. Vitamin D, interleukin (IL)-17, IL-18, immunoglobulin (Ig)A, and IgG were obtained, and the differences between the groups were investigated.
RESULTS: The IL-17 levels in the recurrent tonsillitis group were found to be significantly higher than in the control group (p=0.012). The tissue IgA levels were significantly higher in the recurrent tonsillitis group compared to the hypertrophic tonsil group (p=0.042). In 17 (56.7%) patients in the recurrent tonsillitis group and 12 (40%) patients in the tonsillar hypertrophy group, vitamin D levels were found to be under 20 ng/mL, which is the level of insufficiency.
CONCLUSION: In this study, there was no significant difference between recurrent tonsillitis patients, hypertrophic tonsil patients, and healthy controls in terms of vitamin D, IL-18, IgG, and IgA levels. The IL-17 levels were higher in patients with recurrent tonsillitis and tonsillar hypertrophy patients compared to the control group.