Evaluation of dynamic thiol/disulphide homeostasis and ischemia-modified albumin levels in sudden sensorineural hearing loss
Hilal Yücel1, Abitter Yücel1, Mehmet Erkan Kahraman1, Mustafa Güllüev2, Mehmet Akif Bor3, Ahmet Rıfat Balık4, Özcan Erel4
1Sağlık Bilimleri Üniversitesi, Konya Şehir Hastanesi, Kulak-Burun-Boğaz Anabilim Dalı, Konya, Türkiye
2Özel Erciyes Hastanesi, Kulak-Burun-Boğaz Bölümü, Kayseri, Türkiye
3Sağlık Bilimleri Üniversitesi, Konya Şehir Hastanesi, Klinik Biyokimya Kliniği, Konya, Türkiye
4Yıldırım Beyazıt Üniversitesi, Klinik Biyokimya Anabilim Dalı, Ankara, Türkiye
Keywords: Audiometry, ischemia-modified albumin, oxidative stress, sudden sensorineural hearing loss, thiol/disulfide homeostasis.
Abstract
OBJECTIVE: This study aimed to investigate the role of ischemia-modified albumin and thiol/disulfide hemostasis in idiopathic sudden sensorineural hearing loss (ISSNHL).
METHODS: This prospective study was conducted with volunteers diagnosed with ISSNHL and healthy individuals between November 2018 and June 2019. The study group included 46 patients (27 males, 19 females; mean age: 42.4±12.3 years; range, 18 to 69 years), and the control group included 41 healthy individuals (25 males, 16 females; mean age: 37.8±11.7 years; range, 18 to 65 years). Serum thiol, disulfide, and ischemia-modified albumin were calculated in ISSNHL patients and control groups. The relationship between prognostic factors of disease and blood values was investigated.
RESULTS: The native thiol/total thiol ratio was significantly higher in the control group. Disulfide levels, disulfide/native thiol ratio, and disulfide/total thiol ratio were significantly higher in the patient group.
CONCLUSION: Oxidative stress that is not balanced by an adequate antioxidant defense may play an important role in the etiopathogenesis of ISSNHL.