The effect of topical hemostatic agent ankaferd on the maxillary sinus mucosa
Burhan Yıldırım1, Mehmet Birol Uğur2, Serkan Çorakçı3, Cenk Evren4, Sibel Bektaş5, Fikret Çınar6
1Zonguldak Karadeniz Ereğli Devlet Hastanesi Kbb Kliniği, Zonguldak Türkiye
2Gazi Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, Ankara,
3Zonguldak Atatürk Devlet Hastanesi KBB Kliniği, Zonguldak Türkiye
4Medilife Beylikdüzü Hastanesi Kulak Burun Boğaz Hastalıkları Kliniği, İstanbul, Türkiye
5Gaziosmanpasa Taksim Eğitim Araştırma Hastanesi,patoloji Kliniği, İstanbul, Türkiye
6İstanbul Bilim Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, İstanbul, Türkiye
Keywords: Ankaferd, maxillary sinus mucosa, topical hemostatic agent.
Abstract
OBJECTIVE: This study aims to determine the histopathological effects of ankaferd blood stopper (ABS) in the maxillary sinus.
METHODS: We used 33 healthy albino New Zealand rabbits in the study. We opened their maxillary sinus surgically. We applied ABS (TrauANK) to the right maxillary sinus of 23 rabbits after mucosal damage was done topically with a curette. After traumatizing the left sinuses of the same rabbits, we applied serum physiologic (TrauSP). We applied ABS (IntactANK) to the right maxillary sinus of 10 rabbits without traumatization and serum physiologic (IntactSP) to their left sinus without traumatization. The rabbits were euthanized at the end of the third week and we performed histopathological examination for the sinus mucosa.
RESULTS: Light microscopy of the slides showed increased severity of inflammation, foreign body reaction, serous gland loss, and ciliary loss in the TrauANK compared to the TrauSP group (p=0.003, p<0.001, p<0.01, p<0.001, respectively). There was no significant difference between lamina propriada fibrosis and osteoneogenesis in terms of TrauANK ve TrauSP. None of the parameters showed significant difference between the IntactANK and IntactSP groups.
CONCLUSION: While ABS does not increase the fibrosis of the lamina propria for the control group, it reduces the possibility of postoperative synechiae and, increased severity of inflammation, more foreign body reaction, more serous gland loss and ciliary loss may affect the nasal physiology negatively.