A sinonasal inverted papilloma: an evaluation of 38 cases at a single center
Deniz Arık1, Funda Canaz1, Evrim Yılmaz1, Güneş Deniz Yıldırım1, Ercan Kaya2, Mustafa Fuat Açıkalın1
1Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi Patoloji Anabilim Dalı, Eskişehir, Türkiye
2Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi Kulak Burun Boğaz Anabilim Dalı, Eskişehir, Türkiye
Keywords: Inverted papilloma, sinonasal papilloma, squamous-cell carcinoma.
Abstract
OBJECTIVE: In this study, we review patients with an inverted papilloma who were diagnosed in our clinic and present their clinical and histopathological features.
METHODS: A total of 38 patients (31 males, 7 females; mean age 52.2 years; range 16 to 84 years) who were diagnosed with an inverted papilloma in the Department of Pathology of our institution between January 2009 and January 2016 were retrospectively analyzed. Clinical characteristics of the patients, recurrence and malignant transformation rates were evaluated.
RESULTS: Of the patients, 17 had right-sided and 18 had left-sided involvement. Three patients had bilateral involvement. A squamous-cell carcinoma developed in four patients. In these patients, the tumor was accompanied by an in situ carcinoma and varying degrees of dysplasia. One patient had severe dysplasia and verrucous hyperplastic changes without an invasive carcinoma. The rate of malignant transformation was found to be 10.5%.
CONCLUSION: Our study results show that sinonasal inverted papillomas are neoplasms with local aggressive course and potential recurrence and malignant transformation. Therefore, treatment should be radical surgery.