Abstract

Primary laryngeal extranodal non-Hodgkin’s lymphoma (NHL) is a rare entity, accounting for approximately less than 1% of all primary laryngeal malign tumors. In this article, we report a 62-year-old male who presented with airway obstruction due to a laryngeal mass. A supraglottic mass was detected by indirect laryngoscopy. An emergency tracheotomy was performed due to respiratory distress. Histological examination by morphology and immunohistochemistry showed diffuse large B-cell lymphoma according to the World Health Organization classification. Systemic and local physical and imaging work-up revealed primary NHL of the larynx in stage 1E. Rituxan plus CHOP (R-CHOP) chemotherapy was administrated. Although complete remission was seen, the patient was lost due to heart disease at two years. Because of its rarity, it is of utmost importance to precise pathologic diagnosis for an effective therapeutic approach.